Itching for Answers: How Histamine Relaxes Lymphatic Vessels

In summary:  Excess histamine may impair lymphatic function by reducing vessel contractions, potentially contributing to sluggish flow, stagnation, and fluid congestion.

“In the current issue of Microcirculation, studies by Kurtz et al. [12] and Nizamutdinova et al. [18] together provide new evidence supporting a role for histamine as an endothelial-derived molecule that inhibits lymphatic muscle contraction.”

Source: Microcirculation

The original paper:

Involvement of histamine in endothelium-dependent relaxation of mesenteric lymphatic vessels

"We found that only combined pharmacological blockade of NO and histamine production completely eliminates flow-dependent relaxation of lymphatic vessels, thus confirming a role for histamine as an EDRF in MLVs. We also confirmed the presence of HDC and histamine inside lymphatic endothelial cells."

Source: Microcirculation