Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases

SUMMARY

"The impairment and dysfunction of the brain lymphatic system has crucial roles in age-related changes of brain function and the pathogenesis of neurovascular, neurodegenerative, and neuroinflammatory diseases, as well as brain injury and tumors." (Abstract only.)

HIGHLIGHTS

• The brain lymphatic drainage system may include perivascular pathway, glymphatic system, olfactory/nasal and meningeal lymphatics.

• The brain lymphatic drainage system maintains homeostasis of brain and participates in immune responses and surveillance.

• The integrate function of the brain lymphatic system is dependent on selectivity and complementarity of each component.

• Effectiveness of the brain lymphatic drainage system is regulated under physiological and neuropathological conditions.

• The brain lymphatic drainage system represents novel therapeutic target to treat neurological dysfunctions.

Source: Progress in Neurobiology via Science Direct