"The impairment and dysfunction of the brain lymphatic system has crucial roles in age-related changes of brain function and the pathogenesis of neurovascular, neurodegenerative, and neuroinflammatory diseases, as well as brain injury and tumors." (Abstract only.)
The brain lymphatic drainage system may include perivascular pathway, glymphatic system, olfactory/nasal and meningeal lymphatics.
The brain lymphatic drainage system maintains homeostasis of brain and participates in immune responses and surveillance.
The integrate function of the brain lymphatic system is dependent on selectivity and complementarity of each component.
Effectiveness of the brain lymphatic drainage system is regulated under physiological and neuropathological conditions.
The brain lymphatic drainage system represents novel therapeutic target to treat neurological dysfunctions.