Obesity increases inflammation and impairs lymphatic function in a mouse model of lymphedema

"Obese mice have impaired lymphatic function at baseline that is amplified by lymphatic injury. This effect is associated with increased chronic inflammation, fibrosis, and adipose deposition. These findings suggest that obese patients are at higher risk for lymphedema due to impaired baseline lymphatic clearance and an increased propensity for inflammation in response to injury."

Source: Vascular Biology and Microcirculation