top of page

Mast Cells, Histamine and Lymphatics

Writer's picture: Nina DmitreffNina Dmitreff

Two papers on the relationship between histamines and lymphatic function:


Mast Cell Degranulation Alters Lymphatic Contractile Activity Through Action of Histamine


"In the in vitro mesenteric preparation, mast cell degranulation altered lymphatic contractile activity via the release of a mediator suggested to be histamine and the subsequent activation of H1 receptors. This action could potentially interfere with the expected ability of lymphatic vessels to reduce edema during inflammation."




Itching for Answers: How Histamine Relaxes Lymphatic Vessels


"In the current issue of Microcirculation, studies by Kurtz etĀ al. [12] and Nizamutdinova etĀ al. [18] together provide new evidence supporting a role for histamine as an endothelial-derived molecule that inhibits lymphatic muscle contraction. In particular, Nizamutdinova etĀ al. show that the effects of flow-induced shear stress on lymphatic endothelium are mediated by both nitric oxide and histamine, since only blockade of both prevents contraction strength and frequency from being altered by flow. Separately, Kurtz etĀ al. used confocal microscopy to determine a preferential expression of histamine receptors on the lymphatic endothelium and demonstrated that histamine applied to spontaneously contracting collecting lymphatics inhibits contractions."





32 views0 comments

ComentƔrios


  • Facebook
  • Instagram
  • Twitter

State of Florida License No: MA96544

State of Georgia License No: MT013198

NPI No.: 1124777198

Certified Member Associated Bodywork & Massage Professionals (ABMP)

Member American Massage Therapy Association (AMTA)

Member Florida State Massage Therapy Association (FSMTA)

Member International Cupping Therapy Association (ICTA)


Ā©2024 by The Grove Studio for Natural Healing LLC and Grove Massage Therapy PLLC

LEGAL and DISCLAIMERS

bottom of page